Analyses of long non-coding RNA and mRNA profiling in the spleen of diarrheic piglets caused by Clostridium perfringens type C.
Zunqiang YanXiaoyu HuangWenyang SunQiaoli YangHairen ShiTiantuan JiangShenggui LiPengfei WangShuangbao GunPublished in: PeerJ (2018)
As a result, 2,056 novel lncRNAs and 2,417 differentially expressed genes were found. These lncRNAs shared the same characteristics of fewer exons and shorter length. Bioinformatics analysis identified that two lncRNAs (ALDBSSCT0000006918 and ALDBSSCT0000007366) may be involved in five immune/inflammation-related pathways (such as Toll-like receptor signaling pathway, MAPK signaling pathway, and Jak-STAT signaling pathway), which were associated with resistance and susceptibility to C. perfringens type C infection. This study contributes to the understanding of potential mechanisms involved in the immune response of piglets infected with C. perfringens type C.
Keyphrases
- signaling pathway
- toll like receptor
- long non coding rna
- pi k akt
- immune response
- bioinformatics analysis
- oxidative stress
- epithelial mesenchymal transition
- poor prognosis
- induced apoptosis
- genome wide identification
- genome wide analysis
- inflammatory response
- network analysis
- dendritic cells
- single cell
- transcription factor