Assessment of global long interspersed nucleotide element-1 (LINE-1) DNA methylation in a longitudinal cohort of type 2 diabetes mellitus (T2DM) individuals.

Nagaraj MalipatilMark LuntRam Prakash NarayananKirk SiddalsGabriela Y Cortés MorenoMartin J GibsonHarvest F GuAdrian H HealdRachelle P Donn

Published in: International journal of clinical practice (2018)

In a 14-year longitudinal cohort of T2DM individuals, relations between global LINE-1 DNA methylation status and specific metabolic markers were seen. Also, a higher degree of DNA methylation was predictive of less weight gain over time in women.

Keyphrases

dna methylation
weight gain
genome wide
gene expression
body mass index
birth weight
polycystic ovary syndrome
copy number
cross sectional
glycemic control
pregnancy outcomes