Integrative transcriptome network analysis of iPSC-derived neurons from schizophrenia and schizoaffective disorder patients with 22q11.2 deletion.

Mingyan LinErika PedrosaAnastasia HrabovskyJian ChenBenjamin R PuliafitoStephanie R GilbertDeyou ZhengHerbert M Lachman

Published in: BMC systems biology (2016)

This study has provided evidence for disruption of potential molecular events in SZ patient with 22q11.2 deletion and related our findings from in vitro neuronal cultures to functional perturbations that can occur during brain development in SZ.

Keyphrases

network analysis
bipolar disorder
cerebral ischemia
gene expression
spinal cord
single cell
resting state
rna seq
risk assessment
dna methylation
multiple sclerosis
induced pluripotent stem cells