Atorvastatin is unlikely to prevent rheumatoid arthritis in high risk individuals: results from the prematurely stopped STAtins to Prevent Rheumatoid Arthritis (STAPRA) trial.
Laurette van BoheemenSamina TurkMarian van Beers-TasWouter BosDiane MarsmanEd N GriepMirian Starmans-KoolCalin D PopaAlper van SijlMaarten BoersMichael T NurmohamedDirkjan van SchaardenburgPublished in: RMD open (2021)
In this small set of randomised high-risk individuals, we did not demonstrate a protective effect of atorvastatin on arthritis development. The main reason for the low inclusion was unwillingness to participate; this may also impede other RA prevention trials. Further research to investigate and solve barriers for prevention trial participation is needed.