The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses.
Leslie Z BenetChristine M BowmanShufang LiuJasleen K SodhiPublished in: Pharmaceutical research (2018)
The extended clearance concept is a powerful tool to evaluate drug-drug interactions, pharmacogenomic and disease state variance but evaluating the AUCR-factor may provide a more valuable approach than characterizing rate-determining steps.
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