BCAA metabolism in pancreatic cancer affects lipid balance by regulating fatty acid import into mitochondria.
Klára GotvaldováJitka ŠpačkováJiří NovotnýKamila BaslarováPetr JežekLenka RossmeislováJan GojdaKatarína SmolkováPublished in: Cancer & metabolism (2024)
Our data suggest that BCAA catabolism is required for the import of long chain carnitines (LC-CARs) into mitochondria, whereas the disruption of this link results in the redirection of activated FAs into TG synthesis and its deposition into LDs. We propose that this mechanism protects cells against mitochondrial overload with LC-CARs and it might be part of the universal reaction to amino acid perturbations during cancer growth, regulating FA handling and storage.
Keyphrases
- fatty acid
- amino acid
- cell death
- induced apoptosis
- cell cycle arrest
- simultaneous determination
- papillary thyroid
- oxidative stress
- endoplasmic reticulum
- reactive oxygen species
- squamous cell
- mass spectrometry
- electronic health record
- liquid chromatography
- big data
- solid phase extraction
- lymph node metastasis
- machine learning
- artificial intelligence
- tandem mass spectrometry
- cell proliferation
- electron transfer