Concordance between ER, PR, Ki67, and HER2-low expression in breast cancer by MammaTyper RT-qPCR and immunohistochemistry: implications for the practising pathologist.

Nahla M BadrMohamed ZaakoukQi ZhangDaniel KearnsAnthony KongAbeer M Shaaban

Published in: Histopathology (2024)

RT-qPCR-based assessment of the mRNA expression of ESR1, PGR, ERBB2, and MKI67 showed high concordance with IHC, suggesting that the MammaTyper test on core needle biopsies represents a reliable, efficient, and reproducible alternative for breast cancer classification and refining HER2 low categorisation.

Keyphrases

estrogen receptor
ultrasound guided
poor prognosis
machine learning
deep learning
tyrosine kinase
squamous cell carcinoma
long non coding rna
radiation therapy
breast cancer cells
endoplasmic reticulum