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Recommendations from the Brazilian society of rheumatology for the diagnosis of Sjögren's syndrome (Part I): glandular manifestations (systematic review).

Virgínia Fernandes Moça TrevisaniSandra Gofinet PasotoMarilena Leal Mesquita Silvestre FernandesMaria Lúcia Lemos LopesSonia Cristina de Magalhães Souza FialhoAysa César PinheiroLaura Caldas Dos SantosSimone AppenzellerTania FidelixSandra Lúcia Euzébio RibeiroDanielle Christinne Soares Egypto de BritoTatiana LibórioMaria Carmen Lopes Ferreira Silva SantosLeandro TanureJuliana D Agostino GennariVinicius Tassoni CivileAna Carolina Pereira Nunes PintoFabíola Reis OliveiraJaqueline Martins de SousaSamira Tatiyama MiyamotoValeria Valim
Published in: Advances in rheumatology (London, England) (2019)
The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.
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