R-Ras deficiency does not affect papain-induced IgE production in mice.
Laura KummolaZsuzsanna OrtutayMaria VähätupaStuart PrinceHannele Uusitalo-JärvinenTero A H JärvinenIlkka S JunttilaPublished in: Immunity, inflammation and disease (2017)
Taken together, despite having reduced number of conventional DC's in the R-Ras KO mice and low expression of CD80 on DC's, the R-Ras KO mice are capable of mounting papain-induced IgE responses comparable to that of the WT mice. To our knowledge, this is the first report addressing potential differences in in vivo allergen responses regulated by the R-Ras GTPase.