Antibodies to Cartilage Oligomeric Matrix Protein Are Pathogenic in Mice and May Be Clinically Relevant in Rheumatoid Arthritis.
Changrong GeDongmei TongErik LönnblomBibo LiangWeiwei CaiCecilia Fahlquist HagertTaotao LiAlf KastbomInger GjertssonDoreen DobritzschRickard HolmdahlPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Our findings provide the structural basis for binding a pathogenic anti-COMP antibody to cartilage. The recognized epitope can be citrullinated, and levels of antibodies to this epitope are elevated in RA patients and correlate with higher disease activity, implicating a pathogenic role of anti-COMP antibodies in a subset of RA patients.
Keyphrases
- rheumatoid arthritis
- disease activity
- end stage renal disease
- systemic lupus erythematosus
- ejection fraction
- ankylosing spondylitis
- newly diagnosed
- rheumatoid arthritis patients
- structural basis
- type diabetes
- juvenile idiopathic arthritis
- adipose tissue
- patient reported outcomes
- interstitial lung disease
- binding protein
- insulin resistance
- idiopathic pulmonary fibrosis
- protein protein