Epigenetic Upregulation of H19 and AMPK Inhibition Concurrently Contribute to S-Adenosylhomocysteine Hydrolase Deficiency-Promoted Atherosclerotic Calcification.

Xin DaiSi LiuLokyu ChengTing HuangHonghui GuoDongliang WangMin Xia Wenhua Ling Yunjun Xiao

Published in: Circulation research (2022)

We have confirmed a novel correlation between SAHH deficiency and atherosclerotic calcification and clarified a new mechanism that epigenetic upregulation of H19 and AMPK inhibition concurrently contribute to SAHH deficiency-promoted Runx2-dependent atherosclerotic calcification.

Keyphrases

chronic kidney disease
dna methylation
gene expression
poor prognosis
skeletal muscle
cell proliferation
replacement therapy
signaling pathway
transcription factor
smoking cessation