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Deubiquitylase USP31 Induces Autophagy and Promotes the Progression in Lung Squamous Cell Carcinoma Cells by Stabilizing E2F1 Expression.

Wenjun LiangMingxia YangXiaohua WangYan QianRuichen GaoYujia ShiXuejun ShiLei ShiTing XuQian Zhang
Published in: Current cancer drug targets (2024)
In summary, this investigation proved that USP31 promoted LUSC cell growth and autophagy, at least in part by stabilizing E2F1 expression, which provided a potential therapeutic gene for the treatment of LUSC.
Keyphrases
  • poor prognosis
  • squamous cell
  • cell death
  • endoplasmic reticulum stress
  • signaling pathway
  • oxidative stress
  • binding protein
  • long non coding rna
  • genome wide
  • copy number
  • transcription factor
  • dna methylation