Recently, the use of assisted reproductive technology (ART) has rapidly increased. As a result, an increasing number of people are concerned about the safety of offspring produced through ART. Moreover, emerging evidence suggests an increased risk of cardiovascular disease (CVD) in offspring conceived using ART. In this review, we discuss the epigenetic mechanisms involved in altered DNA methylation, histone modification, and microRNA expression, as well as imprinting disorders. We also summarize studies on cardiovascular changes and other risk factors for cardiovascular disease, such as adverse intrauterine environments, perinatal complications, and altered metabolism following assisted reproductive technology (ART). Finally, we emphasize the epigenetic mechanisms underlying the increased risk of CVD in offspring conceived through ART, which could contribute to the early diagnosis and prevention of CVD in the ART population.
Keyphrases
- dna methylation
- cardiovascular disease
- hiv infected
- high fat diet
- antiretroviral therapy
- gene expression
- type diabetes
- genome wide
- poor prognosis
- pregnant women
- adipose tissue
- metabolic syndrome
- emergency department
- long non coding rna
- coronary artery disease
- skeletal muscle
- binding protein
- copy number
- cardiovascular risk factors
- case control