AAV-mediated AP-1 decoy oligonucleotide expression inhibits aortic elastolysis in a mouse model of Marfan syndrome.

Anca RemesRawa ArifMaximilian FranzAndreas JungmannMarcin Zaradzki Thomas PuehlerMarkus B HeckmannNorbert FreyMatthias KarckKlaus KallenbachMarkus HeckerOliver J Müller Andreas H Wagner

Published in: Cardiovascular research (2022)

This novel approach protects from deterioration of aortic stability by sustained delivery of nucleic acids-based therapeutics and further elucidated how to interfere with the mechanism of elastolysis.

Keyphrases

aortic dissection
mouse model
aortic valve
pulmonary artery
poor prognosis
left ventricular
transcription factor
small molecule
case report
coronary artery
binding protein
gene therapy
pulmonary hypertension
long non coding rna
atrial fibrillation