Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function.
Helen A OwensLauren E ThorburnElisabeth WalsbyOwen R MoonPierre RizkallahSubuhi SherwaniCaroline L TinsleyLouise RogersCamilla CeruttiAnne J RidleyJulie WilliamsVera KnäuperAnn AgerPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.