Simultaneous Targeting of IL-1-Signaling and IL-6-Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm.
Natalia Colás-AlgoraPablo Muñoz-PinillosCristina Cacho-NavasJosé Avendaño-OrtizGema de RivasSusana BarrosoEduardo López-CollazoJaime MillánPublished in: Arteriosclerosis, thrombosis, and vascular biology (2023)
These findings strongly suggest a major role for both IL-6 trans-signaling and IL-1β signaling in the pathological increase in permeability of the human lung microvasculature and reveal combinatorial strategies that enable the gradual control of pulmonary endothelial barrier function in response to a cytokine storm.