Phase I Trial of Autologous RNA-electroporated cMET-directed CAR T Cells Administered Intravenously in Patients with Melanoma and Breast Carcinoma.

Payal Deepak Shah Alexander C Huang George X Xu Robert J Orlowski Ravi K Amaravadi Lynn M Schuchter Paul J Zhang Julia Tchou Tina Matlawski Amanda Cervini Joanne Shea Joan Gilmore Lester Lledo Karen Dengel Amy Marshall E John Wherry Gerald P Linette Andrea Brennan Vanessa E Gonzalez Irina Kulikovskaya Simon F Lacey Gabriela Plesa Carl H June Robert A Anders Tara C Mitchell

Published in: Cancer research communications (2023)

Data evaluating CAR T therapy in patients with solid tumors are limited. This pilot clinical trial demonstrates that intravenous cMET-directed CAR T-cell therapy is safe and feasible in patients with metastatic melanoma and metastatic breast cancer, supporting the continued evaluation of cellular therapy for patients with these malignancies.

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