Ablation of striatal somatostatin interneurons affects MSN morphology and electrophysiological properties, and increases cocaine-induced hyperlocomotion in mice.
Adeline GazanDaniel RialSerge N SchiffmannPublished in: The European journal of neuroscience (2019)
The striatum is mainly composed by medium spiny neurons (95 %) (MSNs). Although outnumbered, in other brain regions such as the hippocampus and the cortex, somatostatin interneurons (SSTi) are known to control and fine-tune the activity of principal cells. This information is still fragmented for the striatum. Here, we questioned the striatal functional consequences of the selective ablation of SSTi in the striatum at the behavioural and cellular levels. We identified increased excitability coupled with decreased distal spine density in MSNs from SSTi-ablated mice. Although the ethological behavioural analysis did not reveal differences between the groups, SSTi-ablated mice were significantly more sensitive to the locomotor effects of cocaine without changes in motivation. This was accompanied by increased expression of the dopamine transporter (DAT) in the ventral striatum. Altogether, we show that SSTi are important players in the maintenance of MSN excitability and spine density impacting on mechanisms towards hyperdopaminergic states.
Keyphrases
- prefrontal cortex
- functional connectivity
- high fat diet induced
- resting state
- induced apoptosis
- spinal cord
- parkinson disease
- spinal cord injury
- poor prognosis
- air pollution
- cell cycle arrest
- genome wide
- cell death
- high glucose
- wild type
- dna methylation
- uric acid
- adipose tissue
- insulin resistance
- diabetic rats
- health information
- cerebral ischemia
- drug induced
- skeletal muscle
- multiple sclerosis
- blood brain barrier
- subarachnoid hemorrhage
- stress induced