Statins in pre-eclampsia or fetal growth restriction: A systematic review and meta-analysis on maternal blood pressure and fetal growth across species.
Lotte MeijerinkKim E WeverFieke TerstappenWessel GanzevoortA Titia LelyMartine DepmannPublished in: BJOG : an international journal of obstetrics and gynaecology (2023)
Our cross-species meta-analyses demonstrate that statins only reduce maternal blood pressure in rodent pregnancies complicated by pre-eclampsia or fetal growth restriction and have no effect on birthweight across species. The broad confidence intervals, inconsistent direction of the observed effects across the studies and large risk of bias lead us to conclude that a solid base for further human RCTs is lacking.
Keyphrases
- blood pressure
- meta analyses
- birth weight
- pregnancy outcomes
- cardiovascular disease
- gestational age
- endothelial cells
- hypertensive patients
- systematic review
- heart rate
- genetic diversity
- randomized controlled trial
- preterm birth
- metabolic syndrome
- type diabetes
- pregnant women
- blood glucose
- body mass index
- insulin resistance
- glycemic control