Focused versus conventional radiotherapy in spinal oncology: is there any difference in fusion rates and pseudoarthrosis?
Oluwaseun O AkinduroGaetano De BiaseAnshit GoyalJenna H MeyerSukhwinder J S SandhuRoman O KowalchukDaniel M TrifilettiJason SheehanKenneth W MerrellSujay A VoraDaniel F BroderickMichelle J ClarkeMohamad BydonJamal McClendonMaziyar A KalaniAlfredo Quiñones-HinojosaKingsley Abode-IyamahPublished in: Journal of neuro-oncology (2022)
Focused radiotherapy may be associated with an improved rate of fusion and clinical pseudoarthrosis when compared to conventional radiation delivery strategies in patients with spinal tumors. Use of autograft at the time of surgery may be associated with improved 12-month fusion rates. Further large-scale prospective and randomized controlled studies are needed to better stratify the effects of radiation delivery modality in these patients.
Keyphrases
- radiation induced
- early stage
- end stage renal disease
- spinal cord
- chronic kidney disease
- newly diagnosed
- locally advanced
- radiation therapy
- minimally invasive
- palliative care
- open label
- double blind
- prognostic factors
- coronary artery bypass
- phase iii
- placebo controlled
- randomized controlled trial
- rectal cancer
- case control
- surgical site infection