Stereoretentive Copper-Catalyzed Directed Thioglycosylation of C(sp2 )-H Bonds of Benzamides.
Amélie ChabrierAlexandre BruneauSara BenmahdjoubBelkacem BenmeradSabrina BelaidJean-Daniel BrionMouâd AlamiSamir MessaoudiPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2016)
An efficient thioglycosylation of C(sp2 )-H bonds with thiosugars has been established for the first time. Using only Cu(OAc)2 ⋅H2 O as a catalyst and Ag2 CO3 as an additive in DMSO, the protocol proved to have broad scope, and a variety of complex thioglycosides have been prepared in good yields with exclusive β-selectivity.