A Novel HIF-2α/ARNT Signaling Pathway Protects Against Microvascular Dysfunction and heart failure After Myocardial Infarction.
Karim UllahLizhuo AiYan LiLifeng LiuQin ZhangKaichao PanZainab HumayunAlbert SitikovQiaozhu SuQiong ZhaoWillard W SharpYun FangDavid WuJames K LiaoRongxue WuPublished in: bioRxiv : the preprint server for biology (2023)
EC-specific deficiencies in Hif2α expression significantly increase cardiac microvascular permeability, promote inflammation, and reduce cardiac function in infarcted mouse hearts, and ARNT overexpression can reverse the upregulation of inflammatory genes and restore endothelial-barrier function in Hif2α-deficient ECs.
Keyphrases
- endothelial cells
- oxidative stress
- signaling pathway
- heart failure
- poor prognosis
- cell proliferation
- left ventricular
- pi k akt
- epithelial mesenchymal transition
- long non coding rna
- genome wide
- induced apoptosis
- atrial fibrillation
- transcription factor
- gene expression
- dna methylation
- binding protein
- cardiac resynchronization therapy
- acute heart failure
- bioinformatics analysis
- genome wide identification