HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.

Yong FuGailing MaYuqian ZhangWenli WangTongguo ShiJie ZhuJunfeng ZhangZhen HuangJiangning Chen

Published in: Inflammatory bowel diseases (2022)

We found that HG-9-91-01 promoted the IL-10 expression of colonic macrophages and exhibited its anticolitis activity through the SIK/CRTC3 axis, and thus it may represent a promising strategy for inflammatory bowel disease therapy.

Keyphrases

ulcerative colitis
poor prognosis
fluorescent probe
aqueous solution
binding protein
stem cells
long non coding rna
cell therapy
bone marrow