Farnesoid X receptor is an important target for the treatment of disorders of bile acid and fatty acid metabolism in mice with nonalcoholic fatty liver disease combined with cholestasis.

Xinzhu LiuJiaxuan WangMaogang LiJiannan QiuXingying LiLi QiJia LiuPing LiuGuoxiang XieXiaoning Wang

Published in: Journal of gastroenterology and hepatology (2023)

All the results suggested that FXR plays a key role in both FA and BA metabolism in NAFLD combined with cholestasis and thus may be a potential target for the treatment of disorders of BA and FA metabolism in NAFLD combined with cholestasis.

Keyphrases

fatty acid
drug induced
metabolic syndrome
combination therapy
binding protein
smoking cessation