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Using simulation to aid trial design: Ring-vaccination trials.

Matt David Thomas HitchingsRebecca Freeman GraisMarc Lipsitch
Published in: PLoS neglected tropical diseases (2017)
Incorporating simulation into the trial design process can improve robustness of sample size calculations. For this specific trial design, vaccine effectiveness depends on properties of the ring vaccination design and on the measurement window, as well as the epidemiologic setting.
Keyphrases
  • study protocol
  • phase iii
  • clinical trial
  • phase ii
  • randomized controlled trial
  • systematic review
  • molecular dynamics
  • molecular dynamics simulations
  • virtual reality
  • placebo controlled