Prevalence and clinicopathological characteristics of lipomatous neurofibromas in neurofibromatosis 1: An investigation of 229 cutaneous neurofibromas and a systematic review of the literature.
Rafaela Elvira Rozza-de-MenezesCarolina de Almeida Ito BrumNicolle Cavalcante GagliononeLilian Machado de Sousa AlmeidaRaquel Machado Andrade-LossoBrenda Vasconcelos Barboza PaivaPedro Leonardo Sanches FaveretAndré Vallejo da SilvaOrlando Hiroshi Kiono SiqueiraVincent M RiccardiKarin Soares CunhaPublished in: Journal of cutaneous pathology (2018)
In NF1, Lnfs are common, mainly in larger tumors and women. All cutaneous NF1-neurofibromas express leptin. It is unknown if the expression of leptin accounts for the lipomatous variant, but it may have a role in the pathogenesis of cutaneous neurofibroma.