The metabolic fuel of paroxysmal nocturnal haemoglobinuria.

Published in: British journal of haematology (2024)

Metabolic reprogramming has been investigated in haematological malignancies. To date, a few studies have analysed the metabolic profile of paroxysmal nocturnal haemoglobinuria (PNH). The study by Chen and colleagues sheds light on the involvement of metabolic changes in the proliferation of PNH clones. Commentary on: Chen et al. The histone demethylase JMJD1C regulates CPS1 expression and promotes the proliferation of PNH clones through cell metabolic reprogramming. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19477.

Keyphrases

atrial fibrillation
blood pressure
obstructive sleep apnea
poor prognosis
gene expression
single cell
physical activity
mesenchymal stem cells
bone marrow
binding protein
catheter ablation
single molecule