Randomized trial of inosine for urate elevation in amyotrophic lateral sclerosis.
David WalkKatharine NicholsonEduardo LocatelliJames ChanEric A MacklinValerie FermentGeorgios E ManousakisMarianne ChaseMariah ConnollyDerek DagostinoMeghan HallJoseph OstrowLindsay PothierCassandra LiebermanDario GelevskiRebecca RandallAlexander V ShermanErin SteinhartDaniela Grasso WalkerJason WalkerHong YuAnne-Marie WillsMichael A SchwarzschildAnna L BeukenhorstJukka-Pekka OnnelaJames D BerryMerit E CudkowiczSabrina PaganoniPublished in: Muscle & nerve (2023)
Inosine met pre-specified criteria for safety and tolerability. A functional benefit was not demonstrated in this trial designed for safety and tolerability. Findings suggested potential utility for a smartphone application in ALS clinical and research settings. This article is protected by copyright. All rights reserved.