Adjunctive Phenobarbital for Alcohol Withdrawal Syndrome: A Focused Literature Review.

Julie A MurphyBrittany M CurranWilliam A GibbonsHolly M Harnica

Published in: The Annals of pharmacotherapy (2021)

In the ED and general medicine ward, phenobarbital demonstrated benzodiazepine-sparing effects. In the ICU, when a protocol guides phenobarbital use, the need for mechanical ventilation may be reduced. Adjunctive phenobarbital was well tolerated. Because of study limitations, it is challenging to provide specific recommendations for adjunctive phenobarbital use in severe AWS.

Keyphrases

mechanical ventilation
intensive care unit
acute respiratory distress syndrome
case report
emergency department
randomized controlled trial
respiratory failure
early onset
clinical practice
drug induced
extracorporeal membrane oxygenation
minimally invasive