Roflumilast as a Potential Therapeutic Agent for Cecal Ligation and Puncture-Induced Septic Lung Injury.

Zafer BayraktutanBusra DincerHalil KeskinDuygu KoseArzu BilenErdem ToktayBusra SirinZekai Halici

Published in: Journal of investigative surgery : the official journal of the Academy of Surgical Research (2021)

ROF, a PDE4 inhibitor, suppressed the expression levels of pro-inflammatory cytokines, alleviated lung damage (probably by blocking neutrophil infiltration), and increased the capacity of the antioxidant system.

Keyphrases

oxidative stress
anti inflammatory
diabetic rats
poor prognosis
high glucose
acute kidney injury
ultrasound guided
binding protein
drug induced
long non coding rna
endothelial cells