NLRP7 deubiquitination by USP10 promotes tumor progression and tumor-associated macrophage polarization in colorectal cancer.

Bing LiZhi-Peng QiDong-Li HeZhang-Han ChenJing-Yi LiuMeng-Wai WongJia-Wei ZhangEn-Pan XuQiang ShiShi-Lun CaiDi SunLi-Qing YaoPing-Hong ZhouYun-Shi Zhong

Published in: Journal of experimental & clinical cancer research : CR (2021)

We showed that NLRP7 promotes CRC progression and revealed an as-yet-unidentified mechanism by which NLRP7 induces the polarization of pro-tumor M2-like macrophages. These results suggest that NLRP7 could serve as a biomarker and novel therapeutic target for the treatment of CRC.

Keyphrases

nlrp inflammasome
poor prognosis
single cell
combination therapy