Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Maxi BeckerDimitris RepantisMartin DreslerSimone KühnPublished in: Human brain mapping (2022)
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. However, brain-functional mechanisms underlying such cognitive enhancing effects of stimulants are still poorly characterized. Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate, modafinil, and caffeine in 48 healthy male adults. The results show that performance in different memory tasks is enhanced, and functional connectivity (FC) specifically between the frontoparietal network (FPN) and default mode network (DMN) is modulated by the stimulants in comparison to placebo. Decreased negative connectivity between right prefrontal and medial parietal but also between medial temporal lobe and visual brain regions predicted stimulant-induced latent memory enhancement. We discuss dopamine's role in attention and memory as well as its ability to modulate FC between large-scale neural networks (e.g., FPN and DMN) as a potential cognitive enhancement mechanism.
Keyphrases
- resting state
- functional connectivity
- working memory
- attention deficit hyperactivity disorder
- neural network
- double blind
- phase iii
- clinical trial
- open label
- autism spectrum disorder
- electronic health record
- climate change
- endothelial cells
- high frequency
- randomized controlled trial
- metabolic syndrome
- risk assessment
- network analysis
- phase ii
- high glucose
- subarachnoid hemorrhage
- diabetic rats
- blood brain barrier
- drug induced