MicroRNA-1 Deficiency Is a Primary Etiological Factor Disrupting Cardiac Contractility and Electrophysiological Homeostasis.
Dandan YangXiaoping WanNeill SchwietermanOmer CavusEge KaciraXianyao XuKenneth R LauritaLoren E WoldThomas J HundPeter J MohlerIsabelle DeschenesJi-Dong FuPublished in: Circulation. Arrhythmia and electrophysiology (2023)
miR1 deficiency acts as a primary etiological factor in inducing cardiac remodeling via disrupting heart regulatory homeostasis. Achieving stable and appropriate microRNA expression levels in the heart is critical for effective microRNA-based therapy in cardiovascular diseases.