Immunoglobulin G1 Antibodies Against Phosphorylcholine Are Associated With Protection in Systemic Lupus Erythematosus and Atherosclerosis: Potential Underlying Mechanisms.
D ThiagarajanR FiskesundA FrostegårdJ SteenM RahmanM VikströmS LundströmJohan FrostegårdPublished in: ACR open rheumatology (2020)
IgG1 anti-PCs are negatively associated with disease activity and disease damage in SLE, but the negative association with CVD is also dependent on confounding risk factors. One potential underlying mechanism could be increased clearance of dead cells.
Keyphrases
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- risk factors
- rheumatoid arthritis patients
- ankylosing spondylitis
- induced apoptosis
- juvenile idiopathic arthritis
- cell cycle arrest
- cardiovascular disease
- human health
- oxidative stress
- type diabetes
- cell proliferation
- signaling pathway
- endoplasmic reticulum stress
- cell death