In situ repair abilities of human umbilical cord-derived mesenchymal stem cells and autocrosslinked hyaluronic acid gel complex in rhesus monkeys with intrauterine adhesion.
Lingjuan WangChuanhu YuTianli ChangMengdi ZhangSu SongChengliang XiongPin SuWenpei XiangPublished in: Science advances (2020)
Increasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord-derived mesenchymal stem cells (huMSCs) loaded on autocrosslinked hyaluronic acid gel (HA-GEL) on endometrial damage and adhesion. Here, we recorded the menstrual cycle data in detail with uterine cavities observed and endometrial tissues detected after intervention, and the thicker endometria, decreased amount of fibrotic formation, increased number of endometrium glands, etc., suggested that both HA-GEL and huMSC/HA-GEL complexes could partially repair IUA caused by mechanical injury, but huMSC/HA-GEL complex transplantation had notable dual repair effects: a reliable antiadhesion property and the promotion of endometrial regeneration.
Keyphrases
- hyaluronic acid
- umbilical cord
- mesenchymal stem cells
- endothelial cells
- wound healing
- induced pluripotent stem cells
- stem cells
- pluripotent stem cells
- biofilm formation
- gene expression
- drug delivery
- endometrial cancer
- systemic sclerosis
- escherichia coli
- pseudomonas aeruginosa
- machine learning
- bone marrow
- idiopathic pulmonary fibrosis
- drug induced
- data analysis