Adenosine-to-inosine (A-to-I) RNA editing is a major source of nucleotide diversification that has significant mechanistic implications in cancer progression and treatment response. However, its activity and prevalence have not yet been systematically determined at a single-cell resolution. Chan and colleagues revealed widespread A-to-I RNA editing events in single cancer cells through an in-depth analysis of a public lung adenocarcinoma single-cell transcriptome dataset. Edits significantly enriched in cancer cells compared to other cell types have the potential to inhibit innate immune response and to predict poor therapeutic response and prognosis in patients treated with targeted therapies. See related article by Chan et al., p. 374.
Keyphrases
- single cell
- rna seq
- immune response
- crispr cas
- high throughput
- healthcare
- nucleic acid
- papillary thyroid
- risk factors
- mental health
- dendritic cells
- toll like receptor
- gene expression
- squamous cell carcinoma
- optical coherence tomography
- squamous cell
- young adults
- lymph node metastasis
- cell therapy
- adverse drug
- childhood cancer