Mitral Regurgitation and Left Ventricular Outflow Tract Obstruction: Confluence of Challenges for Transcatheter Treatment.
Antonio SisinniManuel Barreiro-PérezFrancisco Calvo-IglesiasRodrigo Estévez-LoureiroPublished in: Reviews in cardiovascular medicine (2024)
The intricate interplay between mitral regurgitation (MR) and left ventricular outflow tract (LVOT) obstruction may result in two clinical scenarios: prosthesis-related LVOT obstruction after mitral valve replacement (TMVR) and systolic anterior motion (SAM)-associated MR. This review provides a comprehensive overview of the pathophysiology, risk assessment, and transcatheter interventions for mitigating the likelihood of LVOT obstruction in patients undergoing TMVR. In addition, it extends its focus to SAM-associated MR, elucidating the different aetiological mechanisms contributing to this phenomenon, beyond hypertrophic cardiomyopathy. Transcatheter treatment options, are explored as potential therapeutic strategies, offering insights into their hemodynamic effectiveness and limitations.
Keyphrases
- left ventricular
- hypertrophic cardiomyopathy
- mitral valve
- left atrial
- risk assessment
- patients undergoing
- heart failure
- cardiac resynchronization therapy
- acute myocardial infarction
- contrast enhanced
- aortic stenosis
- magnetic resonance
- randomized controlled trial
- systematic review
- climate change
- blood pressure
- magnetic resonance imaging
- human health
- physical activity
- heavy metals
- mass spectrometry
- atrial fibrillation
- combination therapy
- coronary artery disease
- drug induced