Upregulation of Endothelial DKK1 (Dickkopf 1) Promotes the Development of Pulmonary Hypertension Through the Sp1 (Specificity Protein 1)/SHMT2 (Serine Hydroxymethyltransferase 2) Pathway.
Qianqian WangJingjing TianXuan LiXiaolin LiuTengfei ZhengYachao ZhaoXiao LiHongyu ZhongDongdong LiuWencheng ZhangMeng ZhangMengmeng LiTeng-Fei ZhengPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
Our data provide robust evidence and molecular explanations for the associations between DKK1, redox defense, mitochondrial disorders, and PH and reveal a novel target for PH treatment.
Keyphrases
- pulmonary hypertension
- oxidative stress
- electronic health record
- poor prognosis
- endothelial cells
- signaling pathway
- cell proliferation
- pulmonary artery
- pulmonary arterial hypertension
- big data
- gene expression
- single cell
- amino acid
- single molecule
- dna methylation
- coronary artery
- data analysis
- long non coding rna
- artificial intelligence
- replacement therapy