Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial.

Dariusz OnichimowskiAnita BędźkowskaHubert Ziolkowski Jerzy J Jaroszewski Michał Borys Mirosław Czuczwar Paweł Wiczling

Published in: Pharmacological reports : PR (2020)

The population PK model was successfully developed to describe the time course of meropenem concentrations. The hypoalbuminemia was found to be associated with higher PTA in the CRRT patients after multiple short-term infusions.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
acute kidney injury
clinical trial
prognostic factors
gram negative
phase iii
phase ii
cross sectional