Ibuprofen treatment after the first days of life in preterm neonates with patent ductus arteriosus.

Johan C A de KlerkNanda van PaassenIngrid M van BeynumRobert B FlintIrwin K M ReissSinno H P Simons

Published in: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (2019)

There seems to be a trend to higher effectiveness with the adjusted ibuprofen dosages in preterm neonates before 28 weeks, but it is associated with more reversible side effects.

Keyphrases

low birth weight
preterm infants
gestational age
preterm birth
randomized controlled trial
systematic review
postoperative pain
combination therapy