Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte.

Juan JinYifen ShiJianguang GongLi ZhaoYiwen LiQiang HeHe Huang

Published in: Stem cell research & therapy (2019)

In conclusion, we illustrated that ADSCs-Exo vividly ameliorated DN symptom by enhancing the expression of miR-486 which led to the inhibition of Smad1/mTOR signaling pathway in podocyte. Possibly, ADSCs-Exo was used as a main therapeutic strategy for DN in future.

Keyphrases

diabetic nephropathy
signaling pathway
epithelial mesenchymal transition
cell proliferation
pi k akt
endoplasmic reticulum stress
cell cycle arrest
poor prognosis
long non coding rna
induced apoptosis
cell death
oxidative stress
transforming growth factor
current status
long noncoding rna
wound healing