The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.

Yi-Chieh YangYung-Wei LinWei-Jiunn LeeFeng-Ru LaiKuo-Hao HoChih-Ying ChuKuo-Tai HuaJi-Qing ChenMin-Che TungMichael HsiaoYu-Ching WenMing-Hsien Chien

Published in: Journal of biomedical science (2023)

The current findings unveil novel mechanisms of KSRP which promote malignant progression of ccRCC through transcriptional inhibition and post-transcriptional destabilization of NEDD4L transcripts. Targeting KSRP and its pathways may be a novel pharmaceutical intervention for ccRCC.

Keyphrases

transcription factor
gene expression
binding protein
heat shock
randomized controlled trial
oxidative stress
drug delivery