The Folic Acid and Creatine Trial: Treatment Effects of Supplementation on Arsenic Methylation Indices and Metabolite Concentrations in Blood in a Bangladeshi Population.

Ahlam K AbuawadAnne K BozackAna Navas-AcienJeff GoldsmithXinhua LiuMegan N HallVesna IlievskiAngela M Lomax-LuuFaruque ParvezHasan ShahriarMohammad N UddinTariqul IslamJoseph H GrazianoMary V Gamble

Published in: Environmental health perspectives (2023)

FA supplementation lowered bMMAs and increased bDMAs in a sample of primarily folate-replete adults, whereas creatine supplementation lowered bMMAs. Evidence of the reversal of treatment effects on As metabolites following FA cessation suggests short-term benefits of supplementation and underscores the importance of long-term interventions, such as FA fortification. https://doi.org/10.1289/EHP11270.

Keyphrases

clinical trial
dna methylation
ms ms
randomized controlled trial
physical activity
gene expression
genome wide
heavy metals
open label
phase iii