Characterization of Cardiac Function by Echocardiographic Global Longitudinal Strain in a Cohort of Children with Neurofibromatosis Type 1 Treated with Selumetinib.
Thomas CaiffaAntimo TessitoreAndrea MagnolatoMatilde PetzMarco BobboDaniela ChiccoBiancamaria D'Agata MottoleseAldostefano PorcariEgidio BarbiGianfranco SinagraIrene BrunoPublished in: Paediatric drugs (2022)
Patients with NF1 treated with selumetinib may experience subtle changes in systolic function identified by global longitudinal strain and not revealed by left ventricular ejection fraction. Global longitudinal strain might be useful to monitor cardiac function in this cohort of patients for the duration of therapy.
Keyphrases
- ejection fraction
- aortic stenosis
- left ventricular
- heart failure
- cross sectional
- newly diagnosed
- signaling pathway
- young adults
- end stage renal disease
- acute myocardial infarction
- bone marrow
- prognostic factors
- cardiac resynchronization therapy
- stem cells
- cell proliferation
- pulmonary hypertension
- inflammatory response
- acute coronary syndrome
- pi k akt
- toll like receptor
- replacement therapy