Radiation Therapy Quality Assurance Analysis of Alliance A021501: Preoperative mFOLFIRINOX or mFOLFIRINOX Plus Hypofractionated Radiation Therapy for Borderline Resectable Adenocarcinoma of the Pancreas.
Leila T TchelebiDiana SegoviaKoren SmithQian ShiT J FitzgeraldMichael D ChuongTyler J ZemlaEileen M O'ReillyJeffrey A MeyerhardtEugene J KoayJessica LowensteinArdaman ShergillMatthew H G KatzJoseph M HermanPublished in: International journal of radiation oncology, biology, physics (2024)
Despite rigorous QA, we encountered variability in simulation, contouring, plan coverage, and dose on trial. Although clinical outcomes did not appear to have been affected, findings from this analysis serve to inform subsequent PDAC SBRT trial designs and QA requirements.