MicroRNA-21 expression, serum tumor markers, and immunohistochemistry in canine mammary tumors.

Eman S RamadanNoha Y SalemIbrahim A EmamNaglaa A AbdElKaderHaithem A FarghaliMarwa S Khattab

Published in: Veterinary research communications (2021)

The present study showed that miR-21 was elevated to a greater extent than CA 15-3 (12.84-fold vs. threefold). Tumors that was positive for vimentin immunoreactivity was also associated with an elevation in the levels of miR-21, showing that miR-21 is released from mesenchymal cells. These findings support the hypothesis that miR-21 may be a more sensitive, noninvasive indicator for CMT.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
poor prognosis
stem cells
induced apoptosis
bone marrow
oxidative stress
binding protein