Simvastatin inhibits oral squamous cell carcinoma by targeting TMEM16A Ca2+-activated chloride channel.

Hechen WangTianyu WangZeying ZhangYu FanLan ZhangKuan GaoShuya LuoQinghuan XiaoChang-Fu Sun

Published in: Journal of cancer research and clinical oncology (2021)

Our findings identify a novel anti-tumor mechanism of simvastatin by targeting TMEM16A. Simvastatin may represent an innovative strategy for treating OSCC with high TMEM16A expression.

Keyphrases

poor prognosis