Human-induced pluripotent stem cell-derived cerebral organoid of leukoencephalopathy with vanishing white matter.
Jiong DengJie ZhangKai GaoLing ZhouYuwu JiangJingmin WangYe WuPublished in: CNS neuroscience & therapeutics (2023)
we constructed the first eIF2B mutant cerebral organoids to explore the dynamic brain development process, which provides a platform for further research on the specific pathogenesis of VWM.
Keyphrases
- white matter
- subarachnoid hemorrhage
- endothelial cells
- induced pluripotent stem cells
- high glucose
- cerebral ischemia
- multiple sclerosis
- wastewater treatment
- diabetic rats
- resting state
- high throughput
- brain injury
- drug induced
- pluripotent stem cells
- functional connectivity
- oxidative stress
- blood brain barrier
- wild type