PET-CT guided versus CT-guided biopsy in suspected malignant pleural thickening; a randomised trial.

Duneesha De FonsekaDavid T ArnoldHelena J M SmarttLucy CullifordLouise StadonEmma TuckerAnna MorleyNatalie Zahan-EvansAnna C BibbyGeraldine A LynchEleanor MishraShahul KhanMohammed HarisHenry SteerLeon LewisAlina IonescuJohn HarveyKevin BlythNajib M RahmanAnthony E EdeyChris A RogersNick A Maskell

Published in: The European respiratory journal (2023)

The results do not support the practice of PET-CT to guide pleural biopsies in patients with a previous non-diagnostic biopsy. The diagnostic sensitivity in the CT-only group was higher than anticipated and supports the practice of repeating a CT-guided biopsy following an inconclusive result if clinical suspicion of malignancy persists.

Keyphrases

pet ct
positron emission tomography
ultrasound guided
image quality
dual energy
computed tomography
contrast enhanced
fine needle aspiration
primary care
healthcare
magnetic resonance imaging
open label
randomized controlled trial
clinical trial
study protocol