Masking, maintenance and mimicry: the interplay of cell-intrinsic and cell-extrinsic effects in evolutionary games.

Through analytical and simulation methods we focus on decomposing the cell-intrinsic and cell-extrinsic interactions in a game-theoretic framework for interacting subpopulations in a genetic system. We highlight the ability of extrinsic contributions to arbitrarily alter the evolution of a population of interacting agents. We derive an exact solution to the 1-dimensional Fokker-Planck equation for a two-player genetic system including mutation, selection, drift and games. Examining how the strength of the specific game interactions alters our analytical solution, we validate these theoretical predictions in simulations. We derive expressions for the conditions on the game interactions in this one-dimensional case that mask the cell-intrinsic monoculture landscape dynamics.